The Mercedes-Benz CLS four-door luxury coupe is getting a significant redesign for 2022. The front grille and headlights are new, while the CLS 450 4MATIC model now comes standard with the AMG styling package. What about powertrain selection? The turbocharged six-cylinder engine with mild hybrid technology produces 362 horsepower, while the sportier Mercedes-AMG CLS 53 is rated at 429 horsepower. All models use a nine-speed transmission and all-wheel drive.